What are the implications of these findings for clinical practice and/or further research? Since PCOS is a multifactorial and a complex endocrine disorder, combination therapy can be used for the comprehensive management of PCOS. What do the results of this study add? Combined use of insulin sensitising agents (myo-inositol, D-chiro-inositol and chromium picolinate), antioxidants (N-acetylcysteine and lycopene), and vitamins (vitamin D, biotin and folic acid) is safe and effective in obese and non-obese women with PCOS. We suggest that combination therapy of insulin sensitising agents, antioxidants and vitamins may be a fruitful approach for the management of PCOS.Impact statement What is already known on this subject? Monotherapy of insulin sensitising agents, antioxidants and vitamins is beneficial in the treatment of PCOS. However, both parameters remain unchanged in lean subjects. A significant reduction was observed in body weight and BMI of obese subjects. After 12 weeks of supplementation, a significant improvement was observed in menstrual cyclicity, acne and hirsutism in both obese and lean PCOS patients. You can use the study as a second opinion to make health care decisions. It is created by eHealthMe based on reports of 82 people who take Chromium picolinate and Multivitamin from the FDA, and is updated regularly. Ltd.) providing combination of insulin sensitising agents (myo-inositol, D-chiro-inositol and chromium picolinate), antioxidants (N-acetylcysteine and lycopene) and vitamins (vitamin D, biotin and folic acid) in women with PCOS. The phase IV clinical study analyzes what interactions people who take Chromium picolinate and Multivitamin have. The present study was undertaken to evaluate the efficacy and safety of the supplementation (Trazer F Forte TM-CORONA Remedies Pvt. It is associated with insulin resistance, hyperinsulinemia, hyperandrogenism, oxidative stress and various long-term complications. Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of both developed and developing countries.
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